Unreal Engine 5 supports NVIDIA's DLSS technology, which uses AI to make games run more smoothly on compatible graphics cards by generating additional frames and sharpening images — without the full processing cost of rendering everything natively. Epic has also integrated NVIDIA's ACE tools, which give developers AI-powered options for animating digital human faces and generating NPC speech.

NVIDIA provides Unreal Engine 5 plugins for DLSS 4, which encompasses several AI-powered graphics features: Multi Frame Generation (creating additional frames between rendered ones), Ray Reconstruction (improving lighting quality using machine learning), and Super Resolution (upscaling lower-resolution images to appear sharper). These run on-device using NVIDIA's RTX graphics processors. At Unreal Fest 2024, NVIDIA also released UE5 plugins for its Avatar Cloud Engine (ACE), which includes Audio2Face-3D (AI facial animation driven by audio input), automatic speech recognition, small language models for NPC dialogue, and text-to-speech generation. These are NVIDIA-developed technologies that Epic has integrated into its engine as optional plugins, not Epic-developed AI systems.