Clip Studio Paint offers an AI-powered Colorize feature that automatically fills color into a user's black-and-white line art drawings. The artist provides the line drawing and optional color hints, and the AI generates a colored layer on top.

The Colorize feature uses machine learning technology to automatically colorize line art merged into a single layer, sending image data to a remote AI server for processing. Users can run a basic 'Colorize all' pass or supply a hint layer with rough color blobs to guide the AI's output. According to a 2024 official statement, the feature's model was built from illustration data provided by creators who gave explicit consent for use in machine learning.