Clip Studio Paint offers a Smart Smoothing feature that uses AI deep learning to reduce pixelation and noise when an image is resized or its resolution is changed. Artists use it to clean up low-resolution artwork so it can be printed or to smooth lines that have become blurry after scaling.

Smart Smoothing uses a deep learning model developed by CELSYS in partnership with the ailia SDK framework from ax Inc. and Axcell Corporation, and runs locally on the user's device without requiring an internet connection. It takes a raster image layer as input and produces a smoothed version with reduced jagged edges (jaggies) and pixel noise. The feature was introduced in Clip Studio Paint Ver. 1.9.1 in July 2019 and is available across DEBUT, PRO, and EX editions on Windows, macOS, and iPad.