Audible is deeply integrated with Amazon's Alexa voice assistant, allowing listeners to control playback, browse titles, and navigate their library entirely by voice — without touching a screen. This works on Echo smart speakers, within the Audible app itself (via a built-in Alexa button), and on Ray-Ban Meta smart glasses.

Audible supports a wide range of Alexa voice commands, including "Alexa, play my book," "Alexa, read faster," "Alexa, next chapter," and "Alexa, what's free on Audible?" Alexa was embedded directly into the Audible iOS app for U.S. users and later expanded to the UK, Germany, and Canada, enabling in-app voice control without requiring a separate Alexa device. The integration uses Alexa's voice recognition and natural language processing to understand and execute commands within the Audible environment specifically. Audible is also available on Ray-Ban Meta smart glasses, where the same voice commands work during hands-free listening.